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    gramd4b GRAM domain containing 4b [ Danio rerio (zebrafish) ]

    Gene ID: 326055, updated on 27-Mar-2024

    Summary

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    Official Symbol
    gramd4bprovided by ZNC
    Official Full Name
    GRAM domain containing 4bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-4780
    See related
    Ensembl:ENSDARG00000045506 AllianceGenome:ZFIN:ZDB-GENE-030131-4780
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fd60a08; wu:fd60a08; si:ch73-230f23.1
    Summary
    Predicted to be involved in negative regulation of toll-like receptor 9 signaling pathway and positive regulation of cysteine-type endopeptidase activity involved in apoptotic process. Predicted to act upstream of or within apoptotic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human GRAMD4 (GRAM domain containing 4). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    chromosome: 25
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (19870657..19934653)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (19772685..19836700)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene E3 ubiquitin-protein ligase Hakai-like Neighboring gene cadherin EGF LAG seven-pass G-type receptor 1b Neighboring gene potassium voltage-gated channel, shaker-related, subfamily, member 6 a Neighboring gene potassium voltage-gated channel, shaker-related subfamily, member 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of toll-like receptor 9 signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GRAM domain containing 4b; GRAM domain-containing protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      19870657..19934653
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005163041.4 → XP_005163098.1  GRAM domain-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BA25
      Conserved Domains (1) summary
      cd13221
      Location:521 → 624
      PH-GRAM_GRAMDC4; GRAM domain-containing protein 4 (GRAMDC4) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

    2. XM_009297989.3 → XP_009296264.1  GRAM domain-containing protein 4 isoform X3

      UniProtKB/TrEMBL
      A0A8M3AWK3
      Conserved Domains (1) summary
      cd13221
      Location:494 → 597
      PH-GRAM_GRAMDC4; GRAM domain-containing protein 4 (GRAMDC4) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

    3. XM_005163043.4 → XP_005163100.1  GRAM domain-containing protein 4 isoform X4

      UniProtKB/TrEMBL
      A0A8M2BA69, E7F6T2
      Related
      ENSDARP00000047250.6, ENSDART00000047251.9
      Conserved Domains (1) summary
      cd13221
      Location:488 → 591
      PH-GRAM_GRAMDC4; GRAM domain-containing protein 4 (GRAMDC4) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

    4. XM_021470684.1 → XP_021326359.1  GRAM domain-containing protein 4 isoform X2

      UniProtKB/TrEMBL
      A0A8M2BA43
      Conserved Domains (1) summary
      cd13221
      Location:495 → 598
      PH-GRAM_GRAMDC4; GRAM domain-containing protein 4 (GRAMDC4) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

    5. XM_009297987.3 → XP_009296262.1  GRAM domain-containing protein 4 isoform X2

      See identical proteins and their annotated locations for XP_009296262.1

      UniProtKB/TrEMBL
      A0A8M2BA43
      Conserved Domains (1) summary
      cd13221
      Location:495 → 598
      PH-GRAM_GRAMDC4; GRAM domain-containing protein 4 (GRAMDC4) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

    6. XM_009297988.3 → XP_009296263.1  GRAM domain-containing protein 4 isoform X2

      See identical proteins and their annotated locations for XP_009296263.1

      UniProtKB/TrEMBL
      A0A8M2BA43
      Conserved Domains (1) summary
      cd13221
      Location:495 → 598
      PH-GRAM_GRAMDC4; GRAM domain-containing protein 4 (GRAMDC4) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

    7. XM_005163042.4 → XP_005163099.1  GRAM domain-containing protein 4 isoform X2

      See identical proteins and their annotated locations for XP_005163099.1

      UniProtKB/TrEMBL
      A0A8M2BA43
      Conserved Domains (1) summary
      cd13221
      Location:495 → 598
      PH-GRAM_GRAMDC4; GRAM domain-containing protein 4 (GRAMDC4) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    Nucleotide Protein Strain
    Heading Accession and Version

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